EFFERON
Efferon LPS
Endotoxin and cytokine adsorption
A haemoperfusion cartridge designed to selectively remove bacterial endotoxin and inflammatory mediators from the bloodstream in patients with Gram-negative sepsis and septic shock.
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Selective endotoxin adsorption
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Simultaneous cytokine reduction
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Compatible with standard extracorporeal circuits
OVERVIEW
About this product
Efferon LPS is a single-use haemoperfusion cartridge for extracorporeal blood purification. Its sorbent is engineered with ligands that bind lipopolysaccharide — the endotoxin released by Gram-negative bacteria and the trigger for the inflammatory cascade that drives septic shock — while the porous matrix also captures mid-molecular-weight inflammatory mediators.
The cartridge is placed in a standard blood perfusion circuit driven by a haemoperfusion or CRRT platform. Because the device works by adsorption rather than filtration, it removes target molecules without significant fluid or electrolyte shifts, and can be run alongside continuous renal replacement therapy where kidney support is also required.
Published clinical experience with the cartridge reports faster resolution of septic shock, earlier weaning from vasopressors and mechanical ventilation, and shorter ICU stay compared with standard care in selected patients.
PRODUCT DETAILS
Family
ICU
Supplier
Efferon
Availability
Australia & New Zealand
FEATURES
Key features and benefits
Endotoxin-selective sorbent
Ligand chemistry targets lipopolysaccharide directly at the source of the septic cascade.
Broad mediator capture
The porous matrix additionally adsorbs mid-molecular-weight cytokines circulating in shock.
Haemocompatible design
Sorbent geometry supports blood flow with low pressure drop and preserved platelet counts.
Fits existing platforms
Runs on standard haemoperfusion and CRRT machines already present in most ICUs.
CLINICAL USE
Applications and indications
Gram-negative septic shock
Vasopressor-dependent patients with confirmed or strongly suspected Gram-negative source.
Post-surgical sepsis
Abdominal and thoracic sepsis with high endotoxin load following perforation or anastomotic leak.
Combined organ support
Used in series with CRRT where acute kidney injury accompanies septic shock.
GRAM-NEGATIVE SEPSIS
SEPTIC SHOCK
ENDOTOXAEMIA
SPECIFICATION
Specifications, sizes and models
Therapy
Haemoperfusion — selective adsorption
Target molecules
Endotoxin (LPS) and inflammatory mediators
Circuit
Veno-venous, standard blood lines
Anticoagulation
Heparin or regional citrate per unit protocol
Use
Single use, sterile, single patient
AVAILABLE SIZES & MODELS
Adult cartridge
Standard sorbent volume for adult haemoperfusion
Session configuration
Typically run as one or more sessions of several hours depending on response
TECHNICAL
Important technical information
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Prime the cartridge per the instructions for use before connecting the patient — priming volume and flush sequence matter for sorbent performance.
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Blood flow rate is set within the range specified in the instructions for use; excessive flow reduces contact time.
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Monitor platelet count, fibrinogen and circuit pressures during therapy.
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Therapy is most effective when started early in the shock trajectory rather than as rescue.
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The cartridge is single use — do not attempt to re-prime or reuse after disconnection.
RESOURCES
Instructions for use
Supplied with every cartridge
Clinical evidence pack
Published studies collated by our team
efferon.com
ICU in-service training
Delivered on site before first use
ACCESSORIES
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Blood line set
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Compatible perfusion pump
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Circuit priming solution
This page is a clinical summary for healthcare professionals. Always refer to the manufacturer's instructions for use for full indications, contraindications, warnings and handling requirements.
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